Francesca Boscia Selected Research

Sodium-Calcium Exchanger

3/2016	NCX1 Exchanger Cooperates with Calretinin to Confer Preconditioning-Induced Tolerance Against Cerebral Ischemia in the Striatum.
8/2015	Pharmacological characterization of the newly synthesized 5-amino-N-butyl-2-(4-ethoxyphenoxy)-benzamide hydrochloride (BED) as a potent NCX3 inhibitor that worsens anoxic injury in cortical neurons, organotypic hippocampal cultures, and ischemic brain.
2/2013	NCX1 is a new rest target gene: role in cerebral ischemia.
1/2013	Transcriptional regulation of ncx1 gene in the brain.
1/2013	Genetically modified mice as a strategy to unravel the role played by the Na(+)/Ca (2+) exchanger in brain ischemia and in spatial learning and memory deficits.
1/2012	NCX1 and NCX3: two new effectors of delayed preconditioning in brain ischemia.
1/2011	The NCX3 isoform of the Na+/Ca2+ exchanger contributes to neuroprotection elicited by ischemic postconditioning.
4/2006	Permanent focal brain ischemia induces isoform-dependent changes in the pattern of Na+/Ca2+ exchanger gene expression in the ischemic core, periinfarct area, and intact brain regions.

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Francesca Boscia Research Topics

Disease

13	Brain Ischemia (Cerebral Ischemia) 06/2022 - 04/2006
10	Stroke (Strokes) 06/2022 - 01/2011
8	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 10/2020 - 04/2006
5	Infarction (Infarctions) 06/2022 - 02/2008
5	Hypoxia (Hypoxemia) 12/2013 - 03/2007
4	Ischemia 06/2022 - 12/2007
3	Multiple Sclerosis 01/2021 - 01/2016
3	Alzheimer Disease (Alzheimer's Disease) 01/2020 - 08/2012
3	Seminoma 06/2015 - 03/2011
2	Dementia (Dementias) 12/2022 - 01/2019
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020 - 09/2014
2	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2020 - 01/2016
2	Schizophrenia (Dementia Praecox) 10/2019 - 01/2019
2	Inflammation (Inflammations) 01/2019 - 01/2018
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 12/2022
1	Neuroinflammatory Diseases 01/2020
1	Mental Disorders (Mental Disorder) 10/2019
1	Demyelinating Diseases (Demyelinating Disease) 01/2019
1	Seizures (Absence Seizure) 01/2019
1	Burns 01/2018
1	Pressure Ulcer (Bedsore) 01/2018
1	Central Nervous System Diseases (CNS Diseases) 10/2016
1	Carcinoma in Situ 06/2015
1	Neoplasms (Cancer) 06/2015
1	Memory Disorders (Memory Loss) 01/2013
1	Germ Cell and Embryonal Neoplasms (Germ Cell Tumor) 12/2012
1	Mucopolysaccharidoses 09/2011
1	Mucopolysaccharidosis III (Sanfilippo Syndrome) 09/2011
1	Teratoma (Teratoid Tumor) 03/2011
1	Embryonal Carcinoma 03/2011

Drug/Important Bio-Agent (IBA)

11	Protein Isoforms (Isoforms)IBA 06/2022 - 04/2006
8	Sodium-Calcium ExchangerIBA 03/2016 - 04/2006
6	CalciumIBA 06/2022 - 04/2006
6	Proteins (Proteins, Gene)FDA Link 06/2015 - 03/2007
5	SodiumIBA 06/2022 - 04/2006
4	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 03/2011
4	Oxygen (Dioxygen)IBA 01/2019 - 03/2011
4	sodium-calcium exchanger 1IBA 01/2013 - 11/2009
3	Neuroprotective AgentsIBA 06/2022 - 01/2009
2	beta-N-methylamino-L-alanine (beta-methylamino-L-alanine)IBA 12/2022 - 01/2019
2	AntiportersIBA 06/2022 - 01/2013
2	Estrogens (Estrogen)FDA Link 06/2015 - 12/2012
2	IonsIBA 02/2013 - 04/2006
2	Adenosine Triphosphate (ATP)IBA 12/2007 - 03/2007
1	NeurotoxinsIBA 12/2022
1	CalpainIBA 06/2022
1	Ion Channels (Ion Channel)IBA 01/2021
1	Histone Deacetylases (Histone Deacetylase)IBA 10/2020
1	Histones (Histone)IBA 10/2020
1	Serotonin (5 Hydroxytryptamine)IBA 01/2020
1	nasIBA 01/2020
1	N-acetylserotoninIBA 01/2020
1	Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA 01/2020
1	AntioxidantsIBA 01/2020
1	Amino Acids FDA Link 10/2019
1	ORAI1 ProteinIBA 01/2019
1	Amyloid (Amyloid Fibrils)IBA 01/2019
1	Cyanobacteria ToxinsIBA 01/2019
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2019
1	D-Aspartic Acid (D Aspartate)IBA 01/2019
1	Voltage-Gated Sodium ChannelsIBA 01/2019
1	Dinoprostone (PGE2)FDA Link 01/2018
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2018
1	Pharmaceutical PreparationsIBA 01/2018
1	Interleukin-6 (Interleukin 6)IBA 01/2018
1	Adenosine Triphosphatases (ATPase)IBA 10/2016
1	K Cl- CotransportersIBA 10/2016
1	Sodium-Hydrogen ExchangersIBA 10/2016
1	Calbindin 2IBA 03/2016
1	Calcium-Binding ProteinsIBA 03/2016
1	Myelin-Oligodendrocyte GlycoproteinIBA 01/2016
1	5- amino- N- butyl- 2- (4- ethoxyphenoxy)- benzamide hydrochlorideIBA 08/2015
1	Dihydrotachysterol (AT 10)IBA 08/2015
1	Hormones (Hormone)IBA 06/2015
1	GTP-Binding Proteins (G-Protein)IBA 06/2015
1	Estrogen Receptor betaIBA 06/2015
1	Estrogen ReceptorsIBA 06/2015
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2015
1	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 01/2015
1	LeptinIBA 09/2014
1	N-Methylaspartate (NMDA)IBA 09/2014
1	Large-Conductance Calcium-Activated Potassium Channels (Maxi-K Channels)IBA 09/2014
1	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 12/2013
1	RE1-silencing transcription factorIBA 02/2013
1	Transcription Factors (Transcription Factor)IBA 01/2013
1	NF-kappa B (NF-kB)IBA 01/2013
1	Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)IBA 01/2013
1	Peptides (Polypeptides)IBA 08/2012
1	Phosphotransferases (Kinase)IBA 09/2011
1	EnzymesIBA 09/2011
1	Acetylglucosaminidase (NAGase)IBA 09/2011
1	Heparitin Sulfate (Heparan Sulfate)IBA 09/2011
1	Firefly LuciferasesIBA 03/2011
1	CobaltIBA 03/2011
1	ChromatinIBA 03/2011
1	cobaltous chloride (cobalt(II)chloride)IBA 03/2011
1	Carisoprodol (Soma)FDA LinkGeneric 11/2009
1	Fura-2 (Fura 2)IBA 11/2009

Therapy/Procedure

2	Therapeutics 07/2013 - 01/2013
1	Ischemic Postconditioning 01/2011